Homocysteine - Why Is a High Level Dangerous?

Homocysteine is an amino acid naturally produced in the body, but an excess - known as hyperhomocysteinemia - can be very harmful. Elevated homocysteine levels damage blood vessel walls, causing inflammation and micro-injuries. This promotes the formation of atherosclerotic plaques, which narrow arteries and increase the risk of heart disease.

Additionally, high homocysteine can disrupt blood clotting, raising the risk of clots that may lead to serious events such as heart attacks or strokes.

What Raises Homocysteine Levels?

• Deficiencies in B vitamins (B6, B12, folic acid) disrupt its metabolism, causing accumulation.

• Genetics – mutations in genes responsible for enzymes that break down homocysteine can predispose to elevated levels.

• Lifestyle – smoking, excessive alcohol consumption, lack of exercise, and poor diet contribute to higher homocysteine.

How to Effectively Lower Homocysteine?

1. Eat a diet rich in B vitamins – include meat, fish, eggs, healthy fats, and fermented foods.

2. Avoid harmful substances – reduce alcohol and quit smoking.

3. Stay physically active – regular exercise supports cardiovascular health and helps maintain normal homocysteine levels.

Beyond Vitamins - Alternative Support

• Betaine (trimethylglycine) from beets helps convert homocysteine into methionine, especially when B vitamin levels are low.

• N-acetylcysteine (NAC) supports homocysteine metabolism and regenerates glutathione, a natural antioxidant protecting blood vessels.

• Omega-3 fatty acids (DHA and EPA) from fatty fish or supplements reduce inflammation and support blood vessels.

• Choline from egg yolks, liver, and supplements (e.g., alpha-GPC) helps neutralize homocysteine and supports liver health.

• Probiotics from fermented foods improve B vitamin absorption, crucial for homocysteine metabolism.

• Magnesium and zinc support enzymes that break down homocysteine; sources include mineral water, pumpkin seeds, oysters, and beef.

• Adaptogens like milk thistle support liver function, vital for detoxifying homocysteine.

• Antioxidants (vitamins C, E, glutathione) protect vessels from damage caused by homocysteine.

• Ketogenic or carnivore diets may indirectly lower homocysteine by stabilizing blood sugar and reducing inflammation. Limiting fructose and processed carbs also helps.

Summary

While homocysteine is natural, excess levels threaten cardiovascular health. Regular testing, a diet rich in B vitamins, and an active lifestyle are essential for prevention. Supplementation with betaine, NAC, choline, or omega-3s, along with supporting liver and gut health, is beneficial. A holistic approach based on healthy habits and targeted supplements can significantly reduce risks linked to high homocysteine and improve overall well-being.

Source: Harmonia - Homocysteine - a deadly enemy